首页> 外文OA文献 >INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
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INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS

机译:兔子感染性纤维瘤:III。棉粘病毒中粘黏病毒的序列传播以及与纤维瘤病毒的交叉免疫测试

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摘要

In the experiments presented, Virus myxomatosum was observed to produce only a localized fibromatous or myxomatous orchitis when injected into the testicles of cottontail rabbits. This type of disease was quite unlike the acute fatal illness which the virus caused in domestic rabbits. 10 serial passages of Virus myxomatosum through cottontail rabbits, covering a total elapsed time of 140 days, failed to alter its pathogenicity for domestic rabbits. Although it proved impossible to convert the myxoma virus into fibroma virus by serial passage in cottontail rabbits, it was found that these animals, recovered from myxoma, had a solid resistance to infection with the fibroma virus. Furthermore, their sera possessed neutralizing antibodies effective against the fibroma virus as well as Virus myxomatosum. A similar cross-immunological relationship was observed in the cases of domestic rabbits that had survived an attack of infectious myxoma.
机译:在提出的实验中,当将病毒粘液瘤病毒注射到棉尾兔的睾丸中时,仅产生局部纤维瘤或粘液瘤性睾丸炎。这种疾病与病毒在家兔中引起的急性致命疾病完全不同。病毒粘液病毒通过棉尾兔连续传播10次,总共耗时140天,未能改变其对家兔的致病性。尽管证明不可能通过在棉尾兔中连续传代将粘液瘤病毒转化为纤维瘤病毒,但发现从粘液瘤中恢复过来的这些动物对纤维瘤病毒的感染具有牢固的抵抗力。此外,它们的血清具有对纤维瘤病毒和粘液瘤病毒有效的中和抗体。在感染性粘液瘤发作后存活的家兔中也观察到类似的交叉免疫关系。

著录项

  • 作者

    Shope, Richard E.;

  • 作者单位
  • 年度 1936
  • 总页数
  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
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